To request access to available datasets or request new datasets visit the Data Request Portalopen in new window. For more information on our process for evaluating and adding new datasets see Requesting New RCIF Datasets.

Before accessing the shared datasets listed here, all users must agree not to transfer the data off of the RCIF shared storage systems. Violations of this policy will be referred for disciplinary redress.

Available Datasets

Curated Research Datasets

ABCD

The Adolescent Brain Cognitive Development (ABCD) Study is the largest long-term study of brain development and child health in the United States. 11,528 children ages 9-10 were recruited to track their biological and behavioral development for 10 years through adolescence into young adulthood. The ABCD structural and functional imaging data currently shared by RCIF is from the ABCD Release 2.0 (year 1, baseline) and was obtained through the ABCD-BIDS Community Collection (ABCCopen in new window). DICOM data was converted to Brain Imaging Data Structure (BIDS) data as input to the DCAN Labs ABCD-BIDS MRI (version 0.0.3) processing pipelineopen in new window which outputs Human Connectome Project (HCP) Minimal Preprocessing Pipelines-style dataopen in new window in both volume and surface spaces in BIDS derivative format. Derivative output files for ABCC Release 2.0open in new window are described at https://collection3165.readthedocs.io/en/stable/derivatives/open in new window. Phenotypic data from ABCD Release 5.1 on NDA is also available.

HCP Young Adult

Human Connectome Project- Young Adult (HCP-YA) is a study of 1200 healthy young adult (ages 22-35) subjects from families with twins and non-twin siblings. Unprocessed and preprocessed MR data is available for 1113 subjects. 889 subjects have fully complete data for all of the four 3T MRI modalities in the HCP protocol: structural images (T1w and T2w), resting-state fMRI (rfMRI), task fMRI (tfMRI), and high angular resolution diffusion imaging (dMRI). 46 subjects (all monozygotic twins) have 3T HCP protocol Retest data available. 184 subjects also have 7T multimodal MR scan data available (in addition to 3T MR scans). 95 subjects also have at least some resting-state MEG (rMEG) and/or task MEG (tMEG) data available (in addition to 3T MR scans). More information on the dataset and processing with the HCP pipelines is available in the S1200 Reference Manualopen in new window. Behavioral data can be downloaded from ConnectomeDBopen in new window, User support is available in the hcp-users Google groupopen in new window. To get started, create a ConnectomeDB account and sign the Open Access Data Use Terms.

CRHD projects apply HCP-style data collection protocols toward subject cohorts at risk for, or suffering from, diseases or disorders affecting the brain, with a goal of providing comparable data to healthy HCP subjects across the lifespan.

Currently available CRHD datasets:

BANDA

The Boston Adolescent Neuroimaging of Depression and Anxiety (BANDA)open in new window is a study of 215 adolescents, ages 14-17, 152 of whom had a current diagnosis of a DSM-5 anxious and/or depressive disorder. BANDA data includes: unprocessed (up to 207 subjects) and HCP pipelines minimally preprocessed (up to 203 subjects) structural MRI, resting state fMRI, task fMRI for 3 tasks, and diffusion MRI. Clinical and behavioral data for 215 subjects is available on NDAopen in new window. More information is available in the BANDA Release 1.1 Reference Manual and other documentationopen in new window to help with understanding the project and interpreting the data.

PDC/MDD

The Perturbation of Treatment-Resistant Depression Connectome by Fast-Acting Therapies (PDC, a.k.a. MDD)open in new window is a study of adults with and without treatment resistant depression (191 patients, 51 controls) and with and without fast-acting treatment interventions (ages 20-64, with treatment-resistant depression treated with ECT [N=44], ketamine [N=67], or total sleep deprivation [N=60], plus healthy controls [N=51]). Of the healthy controls, 16 underwent total sleep deprivation and 17 were assessed at 2 visits without intervention. PDC data includes: unprocessed (227 subjects) and HCP pipelines minimally preprocessed (218 subjects) structural MRI, resting state fMRI, task fMRI for 3 tasks, and diffusion MRI. Clinical and behavioral data for 230 subjects is available on NDAopen in new window. More information is available in the PDC Release 1.0 Reference Manual and other documentationopen in new window to help with understanding the project and interpreting the data.

CT-RATE

CT-RATE is a dataset that uniquely pairs textual data with imagery data comprised of chest CT volumes paired with corresponding radiology text reports, multi-abnormality labels, and metadata. The CT-RATE dataset is released as part of the paper "A foundation model that utilizes chest CT volumes and radiology reports for supervised-level zero-shot detection of abnormalities". CT-RATE consists of 25,692 non-contrast chest CT volumes, expanded to 50,188 through various reconstructions, from 21,304 unique patients, along with corresponding radiology text reports, multi-abnormality labels, and metadata. To get started, go to https://huggingface.co/datasets/ibrahimhamamci/CT-RATEopen in new window, create a Hugging Face account and sign the CT-RATE Data Use Terms.

OASIS

The Open Access Series of Imaging Studies (OASIS) is a series of studies of aging and dementia in middle-aged to older adults. See https://www.oasis-brains.org/#aboutopen in new window. The studies include:

OASIS 1 - Cross-sectional MRI Data in Young, Middle Aged, Nondemented and Demented Older Adults
OASIS-2: Longitudinal MRI Data in Nondemented and Demented Older Adults
OASIS-3: Longitudinal Multimodal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer’s Disease
OASIS3AV1451: Baseline OASIS-3 Flortaucipir F18 (AV1451) PET
OASIS3AV1451L: Longitudinal OASIS-3 Flortaucipir F18 (AV1451) PET
OASIS-4: Clinical Cohort, aged 21-94 To get started, go to https://www.oasis-brains.org/#accessopen in new window, and click Apply to Access OASIS Data.

UK Biobank

UK Biobank holds an unprecedented amount of data on half a million participants aged 40-69 years (with a roughly even number of men and women) recruited between 2006 and 2010 throughout the UK. Our copy of the dataset includes brain MRI, heart MRI, abdominal MRI, genotypes, and phenotypes. Brain imaging includes structural MRI, functional MRI, diffusion MRI, and susceptibility weighted MRI for over 40k session 1 and 3,400+ session 2 longitudinal subjects. Publication of image processing https://pubmed.ncbi.nlm.nih.gov/29079522/open in new window. Our copy is managed by the Bijsterbosch lab who have provided documentation for use on the CHPC: UK_Biobank_use. To get started, create a Biobank account: https://ams.ukbiobank.ac.uk/ams/signupopen in new window

TCIA

The Cancer Imaging Archive (TCIA) is a series of radiology and histopathology imaging datasets. Imaging collections include data related to the images such as patient outcomes, treatment details, genomics, pathology, and expert analyses that are also provided or linked to when available. Collections are described at https://www.cancerimagingarchive.net/collections/open in new window.

Currently available TCIA datasets:

Breast-Cancer-Screening-DBT

A curated dataset of digital breast tomosynthesis (DBT) images that includes normal, actionable, biopsy-proven benign, and biopsy-proven cancer cases. The dataset contains four components: (1) DICOM images, (2) a spreadsheet indicating which group each case belongs to (3) annotation boxes, and (4) Image paths for patients/studies/views. https://www.cancerimagingarchive.net/collection/breast-cancer-screening-dbt/open in new window

Duke-Breast-Cancer-MRI

A retrospective collection of 922 biopsy-confirmed invasive breast cancer patients including demographic, clinical, pathology, treatment, outcomes, genomic data, and dynamic contrast- enhanced (DCE) MRI. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=70226903open in new window

ISPY TRIAL

Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis is a national prospective study to test MRI for ability to predict response to treatment and risk-of-recurrence in patients with stage 2 or 3 breast cancer receiving neoadjuvant chemotherapy. Criteria for inclusion were patients with T3 tumors measuring at least 3 cm in diameter by clinical exam or imaging and receiving neoadjuvant chemotherapy with an anthracycline-cyclophosphamide regimen alone or followed by a taxane. This collection includes 230 patients. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=20643859open in new window

ISPY1-Tumor-SEG-Radiomics

This dataset enhances the ISPY1 breast cancer data collection, with uniformly curated data, tumor annotations, and quantitative imaging (also known as radiomic) features corresponding to the tumor regions in 163 subjects. The segmentations included are for the entire 3D primary lesion, including both the enhancing and the non-enhancing tumor regions, therefore defining the structural tumor volume (STV) to allow analyses of the entire disease burden and analyses of tumor heterogeneity regarding contrast uptake. https://www.cancerimagingarchive.net/analysis-result/ispy1-tumor-seg-radiomics/open in new window

ISPY2

Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis 2 is an ongoing, multi-center trial designed to quickly evaluate the efficacy of new agents for breast cancer in neoadjuvant chemotherapy (NAC) setting. 719 patients are included in this collection. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=70230072open in new window

Pancreas-CT

A collection of 82 abdominal contrast enhanced 3D CT scans from 53 male and 27 female subjects. Seventeen of the subjects are healthy kidney donors scanned prior to nephrectomy. The remaining 65 patients were selected by a radiologist from patients who neither had major abdominal pathologies nor pancreatic cancer lesions. https://www.cancerimagingarchive.net/collection/pancreas-ct/open in new window

QIN_Breast_DCE-MRI

A collection of breast dynamic contrast-enhanced (DCE) MRI data from a longitudinal study to assess breast cancer response to neoadjuvant chemotherapy. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=18514286open in new window

VICTRE

The VICTRE Trial is an open-source, in-silico clinical trial to investigate a new paradigm for evaluating digital breast tomosynthesis (DBT) as a replacement for digital mammography (DM). A total of 2986 subjects, with breast sizes and radiographic densities representative of a screening population and compressed thicknesses from 3.5 to 6 cm, were simulated and imaged on in-silico versions of DM and DBT systems using fast Monte Carlo x-ray transport. Images were interpreted by a computational reader detecting the presence of lesions. The in-silico trial (VICTRE) was designed to replicate a comparative trial from a previous regulatory submission. https://www.cancerimagingarchive.net/collection/victre/open in new window

BJC Bulk Clinical Data Sets

These clinical datasets have been retrieved from the BJC Hospital System Picture Archiving and Communication Systems (PACS) for analysis.

Currently available BJC Bulk Clinical Data Sets:

MAMMO-BJH-1

458,486 de-identified screening and diagnostic mammograms acquired in St. Louis at Barnes Jewish Hospital, the Center for Advanced Medicine and the BJH Mammography Van, for dates 01/01/2008-04/08/2020. IRB #201706058

Requesting Datasets

Requests for listed datasets, additional datasets, or transfer of clinical data from PACs for research purposes can be made through the Data Request Portalopen in new window.